Еvolution of methods, technologies and materials for bone tissue defects replacement (review) Khominets V.V., Kalyuzhnaya-Zemlyanaya L.I., Grankin A.S., Fedorov R.F., Volov D.A., Komarov A.V. 25
Influence of type of endoprosthesis during alloplastic reconstruction in breast cancer patients on the frequency of postoperative complications and quality of life
Steroid metabolomics in women with non-classic congenital adrenal hyperplasia in the presence and absence of adrenocortical masses or multifollicular ovarie
Macrotroponins in the blood as an analytical problem and solutions (review and personal experience)
Sheshurina T.A., Dorofeykov V.V.84
Regional features of frequencies distribution of gene polymorphism of arterial hypertension in northern residents of the Magadan region
Bezmenova I.N. 89
TO AUTHORS ATTENTION
HYGIENE
EVALUATION OF THE CONTENT OF SUSPENDED SUBSTANCES RM 10 AND RM 2.5 IN THE ATMOSPHERIC AIR OF SAINT PETERSBURG
L.A. Alikbaeva, S.P. Kolodiy, D.O. Stashkova, I.Sh. Iakubova, N.N .Krutikova, A.N. Moshchev, A.L. Ryzhkov North-Western State Medical University named after I.I. Mechnikov. Russia, 191015, Saint Petersburg, Kirochnaya street, 41 Abstract Introduction. Atmospheric air pollution in large cities is an urgent problem within the organization of ensuring the sanitary and epidemiological well-being of the population. One of the indicators for assessing air quality is the determination of the content of microfine dust particles posing the greatest danger to public health due to their small size. The aim of the study was to provide a hygienic assessment of air pollution in Saint-Petersburg with suspended solids. Materials and methods. The air quality assessment was carried out on the basis of data obtained from 25 automatic air pollution monitoring stations located in various districts of Saint- Petersburg during 2017-2021. The analysis of the obtained data on the content of suspended substances PM10, PM2.5 in the air was performed. Results. The hygienic assessment showed that the content of suspended particles PM10 and PM2.5 in the atmospheric air increased in the spring and summer periods, while the maximum growth of particulate matter was detected in April, due to the climatic conditions of the region. Conclusion. In order to ensure the optimization of road maintenance in the summer period, it is necessary to amend the “Regulations for the performance on the regional roads maintenance in Saint- Petersburg” in terms of the timing, change the start date of summer road maintenance from April 16 to March 16, because the content of suspended solids in the atmospheric air of Saint-Petersburg occurs in March. Keywords: pollution, atmospheric air, suspended solids, road transport complex.
DIAGNOSIS, TREATMENT, EPIDEMIOLOGY, PREVENTION OF DISEASES
QUALITY OF LIFE IN PATIENTS WITH ATRIAL FIBRILLATION AFTER OCCLUDER ENDOVASCULAR IMPLANTATION OR EPICARDIAL RESECTION OF THE LEFT ATRIAL APPENDAGE
S.A. Sayganov, A.V. Sotnikov, M.V. Mel’nikov, V.V. Semenyuta, D.A. Yakovlev, A.V. Potapova, L.A. Bilalova, Yu.A. Starostina North-Western State Medical University named after I.I. Mechnikov. Russia, 191015, Saint Petersburg, Kirochnaya street, 41 Abstract Introduction. There are no data on comparative results of occluder endovascular implantation or epicardial resection of the left atrial appendage in patients with atrial fibrillation. Aim of the study was to compare the quality of life in patients with atrial fibrillation after open left atrial appendage removal or occluder endovascular implantation. Material and methods. This was a single-center prospective observational study using the SF-36 questionnaire. In group 1 (n=34), the removal of the left atrial appendage was performed simultaneously with the other open-heart surgeries (coronary bypass surgery and/or heart valve repair). Average age of patients was 67.5±8.8 years, including 13 female patients (38.2%), follow-up period was from 6 to 18 months. In group 2 (n=14), endovascular occluder implantation of the left atrial appendage was performed as an independent isolated procedure. Patients of this group were older than 73.1±6.9 years (p=0.045), including 5 female patients (35.7%), follow-up period was from 6 to 18 months. The multivariate analysis of covariance was performed in the Statistica 12. Results. The quality of life in group 1 in comparison with group 2 was significantly better by the following values: body pain (81±1.1 vs 55.6±1.2, p=0.038), general health (65.9±1.1 vs 29.2±1.2, p<0.001), vitality (55.9±1.2 vs 31.5±1.2, p=0.038), social functioning (87.5±1.1 vs 59.7±1.1, p=0.006), role functioning due to emotional state (72.4±1.3 vs 13.1±1.5, p=0.001), mental health (78.6±1.1 vs 35.4±1.2, p<0.001). Conclusion. A comparison of the quality of life in patients with atrial fibrillation after open removal of the left appendage or occluder endovascular implantation showed the advantages of open removal in most scores of the SF-36 questionnaire, provided simultaneous surgical correction of other structural cardiac pathology. Keywords: atrial fibrillation, quality of life, occluder of the left appendage, surgical treatment.
BIOPROSPECTING OF POTENTIAL PRODUCERS OF NEW ANTIMICROBIAL COMPOUNDS IN TERRESTRIAL ECOSYSTEMS OF ANTARCTICA
B.I. Aslanov 1, A.E. Goncharov 2,1, D.V. Azarov 2,1, E.A. Lebedeva 1,
K.V. Gusarova 1, A.P. Solomenny 3, V.V. Kolodzhieva 1 1North-Western State Medical University named after I.I. Mechnikov. Russia, 191015, Saint Petersburg, Kirochnaya street, 41 2 Institute of Experimental Medicine. Russia, 197376, Saint Petersburg, Academician Pavlov Street, 12 3Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences –Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences. Russia, 614081, Perm, Goleva Street, 13 Abstract Introduction. The extremely cold biogeocenosis of the Arctic and Antarctica are considered as the most promising sources of new antimicrobial compounds. The aimof the study was to identify bacterial producers of antimicrobial compounds in terrestrial ecosystems of Antarctic oases. Materials and methods. The antagonistic activity of a collection of 98 Antarctic mesophilic bacteria was tested by double-layer agar using epidemic MRSA, multiantibiotic-resistant strains of Escherichia coli, erythromycin-resistant strains of Streptococcus pyogenes and Streptococcus agalactiae as indicator strains. Genomic sequencing of Bacillus safensis strain 440-1 was performed to detect the genes of antimicrobial peptides. Results and discussion.It was identified10 strains of Antarctic bacteria antagonistic to opportunistic and pathogenic bacteria. The genome of the Bacillus safensis strain 440-1, showed pronounced antagonistic activity towards indicator cultures containing genes of antimicrobial peptides (plantozolicin–like factor, pumilarin-like protein, lantibiotic-like protein), and does not contain genes of pathogenicity factors. It is concluded that the Antarctic strain Bacillus safensis 440-1 has prospects for practical application as a producer of antimicrobial peptides or probiotic. Conclusion.Bioprospecting of antimicrobial drug producers in the natural ecosystems of the polar regions of Earth is an effective strategy for finding alternatives to classical antibiotics, while significant attention should be paid to the Bacillus genus. Keywords: bioprospecting, Antarctica, extremophiles, antibiotic resistance, antimicrobial peptides, genomic sequencing. EVOLUTION OF METHODS, TECHNOLOGIES AND MATERIALS FOR BONE TISSUE DEFECTS REPLACEMENT (REVIEW)
V.V. Khominets, L.I. Kalyuzhnaya-Zemlyanaya, A.S Grankin, R.F. Fedorov, D.A. Volov, A.V. Komarov S.M. Kirov Military Medical Academy. Russia, 194044, Saint -Petersburg, Akademika Lebedeva street, 6
Abstract
Traditional methods of bone defect replacement have been demonstrated a relatively new approach to the problem of bone defect replacement. But all of them have advantages and disadvantages. The existing traditional techniques for the replacement of significant bone tissue defects do not fully satisfy clinicians. Therefore, the search for new promising techniques, based on fundamental studies of reparative osteogenesis, some of which have been revised in last years, is necessary. Meanwhile, the fundamental studies of recent years in the field of tissue engineering allow to consider new ways of repairing bone tissue defects for their application in clinical practice.
The aim of the study was to analyze the development of most common methods of bone tissue replacement and search for promising tissue engineering solutions; to compare modern methods of bone defects replacement, based on the analysis of available scientific publications, and to determine the most promising direction for research and application in clinical practice.
Conclusion. The full-fledged alternative of autologous bone graft search leads to necessity of using "uncommon" biologically active materials with high osteoinduction. One of the promising techniques, from our point of view, is the use of extracellular matrix from provisory organs, which also has high osteogenic activity, but being safe in use and relatively easy to manufacture. Keywords: biomaterials, extracellular matrix, Wharton's jelly, scaffold, hydrogel, tissue engineering, bone tissue, bone regeneration, biopolymers, 3D printing, provisory organs.
INFLUENCE OF TYPE OF ENDOPROSTHESIS DURING ALLOPLASTIC RECONSTRUCTION IN BREAST CANCER PATIENTS ON THE FREQUENCY OF POSTOPERATIVE COMPLICATIONS AND QUALITY OF LIFE
M.A. Monogarova 1, E.M. Bit-Sava 1,2, A.L. Istranov 3, M.G. Kurbanova 1, A.O. Damenia 1, B.N. Isich 4,V.M. Moiseenko 1 1Saint- Petersburg clinical scientific and practical center for specialised types of medical care (oncological). Russia, 197758, Saint Petersburg, Pesochny settlement, Leningradskaya street, 68A, lit. A 2Saint-Petersburg State Pediatric Medical University. Russia, 194100, Saint-Petersburg, Litovskaya street, 2 3 I. M. Sechenov First Moscow State Medical University. Russia, 119991, Moscow, Trubetskaya street, 8, p. 2 4The First St. Petersburg State Medical University named after Academician I.P. Pavlov. Russia, 197022, Saint-Petersburg, Leo Tolstoy street, 6-8 Abstract Introduction. The share of alloplastic breast reconstruction is 80.0% of all cases of simultaneous recovery, but it remains unclear what type of endoprostheses are most preferred in breast cancer patients. The aim of the study was to evaluate the effect of the type of endoprosthesis on the frequency of postoperative complications and the quality of life of breast cancer patients with simultaneous reconstructive plastic surgery. Materials and methods. The assessment of the frequency of postoperative complications and quality of life in 163 breast cancer patients, depending on the type of endoprosthesis, was carried out. Results. The frequency of postoperative complications after subcutaneous /skin–preserving mastectomy with simultaneous reconstruction with implants was 23,3%, double–lumen endoprostheses – 11,0%, expander with subsequent replacement with an implant – 3,7%. In 29 cases the resulting complications required the removal of the endoprosthesis. The main risk factors for the postoperative complications were: axillary lymph node dissection, neoadjuvant and adjuvant chemotherapy, remote radiation therapy, age over 55 years, diabetes mellitus, body mass index less than 20 and above 25, smoking. The use of intraoperative radiation therapy during reconstruction in patients with luminal A tumor over the age of 62 years reduces the risk of infectious complications caused by remote radiation therapy by 10,4% in the group of patients using endoprostheses (implant or expander/implant). The use of sentinel lymph node biopsy during simultaneous reconstructive plastic surgery reduces the risk of developing lymphorrhea with postoperative wound infection by 8,8% and protrusion/extrusion of the endoprosthesis by 12,6%. Conclusion. Assessment of risk factors for postoperative complications when using different types of endoprostheses during alloplastic reconstruction in breast cancer patients could improve the quality of life and the aesthetic result of the operation. Key words: breast, breast cancer, quality of life, postoperative complications, risk factors, breast endoprosthesis, subcutaneous/skin-preserving mastectomy, alloplastic reconstruction.
INFLUENCE OF TYPE OF LABOR AND MICROBIAL CONTAMINATION OF FACE MASK ON THE ADVERSE SKIN REACTIONS TO ITS WEARING
E.A. Shashina First Moscow State Medical University. Russia, 119991, Moscow, Trubetskaya street,8 Abstract Introduction. The need to use face masks and the prevalence of adverse reactions to their wearing highlights the priority to study the factors influenced their frequency and severity. In this article was analyzed adverse skin reactions and the factors that influence them. The aimof the study was to identify the influence of the type of labor and microbial contamination of face mask on the appearance of adverse skin reactions to its wearing. Material and methods. The study included two groups: students and transport workers, corresponding to each other in terms of gender and age and wearing masks for 2 hours. Next, the study participants filled out a questionnaire, where they subjectively assessed wearing comfort and the severity of adverse skin reactions on a single scale. From the inside of the used masks, immediately after wearing, swabs were taken and the total microbial count per unit volume of the wash fluid was determined according to the standard method. Results and discussion. In transport workers engaged in moderate physical labor, facial hyperhidrosis, skin redness / peeling / itching, skin rashes after wearing a face mask were more pronounced (p <0.001), and comfort was lower compared to students (p = 0.025), whose work could be classified as light. The number of microorganisms on the masks of transport workers was higher compared to the masks of students, regardless of the material of the mask (p<0.05). A moderate positive relationship was found between the microbial contamination of the inner surface of the face mask and the severity of skin rashes after wearing (r = 0.454, p = 0.10). Conclusion. Adverse skin reactions to wearing a face mask depend on the severity of the wearer's work. Microbial contamination of the inner surface of the mask as a result of wearing also depends on the severity of the wearer's work. Microbial contamination of a face mask is one of the factors influencing the appearance of adverse skin reactions. Key words: students, transport workers, face masks, skin reactions to wearing a face mask, microbial contamination of the face mask, facial hyperhidrosis, skin redness, facial skin rashes.
EPIDEMIOLOGICAL EVALUATION OF RISK FACTORS FOR PREGNANCY LOSS (REVIEW)
O.V. Shirai 1,2, B.I. Aslanov 1, S.V. Rishchuk1, T.M. Chirkina 1 , Belova L.V. 1 1 North-Western State Medical University named after I.I. Mechnikov. Russia, 191015, Saint- Petersburg, Kirochnaya Street, 41 2St. Elizabeth City Hospital, Russia, 195257, Saint- Petersburg, Vavilov Street, 14 Abstract
Pregnancy loss is an urgent problem for the medical community, as it is a multifactorial condition combining various disorders both in the reproductive system and in the female body as a whole. The main causes of spontaneous abortion include genetic factors, sexually transmitted infections, congenital and acquired uterine pathology, somatic, endocrinological, immunological, hemostasiological, acute and chronic infectious diseases. The demographic situation in the Russian Federation in recent years continues to deteriorate. So in 2020 there were born 9.8 per 1000 population, died 14.6; in 2021 there were born 9.6 per 1000 population, died 16.7. Thus, the natural decline in population in 2020 was minus 4.8, in 2021 - minus 7.1. High mortality and low birth rate during this period entailed natural population decline, including due to the COVID-19 pandemic. In this connection, the epidemiological assessment of the risk factors for pregnancy failure at the present stage is an urgent task and is necessary to optimize the organization of medical care for women with this pathology and, as a consequence, to improve the demographic situation as a whole. It was conducted a literature review of relevant scientific papers from 2016 to 2022 using PubMed, eLIBRARY, Google Scholar and Medline. This study included publications containing evidence-based experimental and clinical evidence on the most current issues related to the risk factors for pregnancy failure. The analysis of the publications allowed to assess the current position of specialists of various fields regarding the risk factors of pregnancy loss. Given that medical organizations should be based primarily on preventive measures, the development of evidence-based algorithms is crucial for the prevention of reproductive losses. Key words: pregnancy loss, risk factors, reproductive losses, demographics, blighted ovum, reproductive health, medical care for women, miscarriage.
PUBLIC HEALTH, ORGANIZATION AND SOCIOLOGY OF HEALTH CARE
ORGANIZATIONAL ASPECTS OF OPTIMIZATION OF SCREENING FOR SKIN NEOPLASMS ON THE BASIS OF THE RISK SCALE
A.N. Barinova, M.V. Gusarov, B.M. Tayts, S.L. Plavinskij North-Western State Medical University named after I.I. Mechnikov. Russia, 191015, Saint-Petersburg, Kirochnaya street, 41 Abstract Introduction. Euromelanoma is a pan-European skin cancer prevention campaign launched in 1999 to provide the public with information about the prevention, early diagnosis and treatment of skin cancer. The campaign is dedicated to the promotion of primary and secondary prevention of skin cancer in Europe. The goal of the campaign is to reduce the burden of melanoma. It has been held in Russia since 2007. Material and methods. It was studied the data of the Melanoma Diagnosis Day (DDM) in Russia in 2021. The data was received from the campaign organizer. Each questionnaire was evaluated with a melanoma risk calculator and assigned to the appropriate risk group. The risk groups were compared with each other. Patients with malignant skin neoplasms with or without different risk factor were also compared. Results. It has been established that melanoma, basal cell carcinoma and malignant skin neoplasms in general are significantly more often detected in the medium-high risk group. In addition, malignant skin neoplasms in general are significantly more often detected in patients older than 60 years and in patients who had severe sunburn before the age of 18. Conclusions. To improve the effectiveness of skin cancer screening, it is recommended to focus on patients in the medium-high risk group, as well as patients over 60 years of age and patients with severe sunburn up to 18 years of age. Key words: Euromelanoma, melanoma diagnosis day, screening, melanoma, basal cell carcinoma, malignant skin neoplasms.
MEDICAL AND SOCIAL PROBLEMS OF VACCINATION
O.A. Denisova 1, A.P. Denisov 1,2, V.V. Drobyshev 3 1Omsk State Medical University. Russia, 12644099, Omsk, Lenina street, 12 2Research Institute for Complex Problems of Hygiene and Occupational Diseases. Russia, 23654041, Novokuznetsk, Kutuzova street, 23 3 Omsk State Pedagogical University. Russia, 644099, Omsk, embankment named after Tukhachevsky street, 14 Abstract Introduction. Total vaccination of the population makes it possible to reduce the risks and threats of epidemics, premature death, disability, etc. However, an ambiguous attitude towards vaccination leads to insufficient adherence of a part of the society. Aim of the study to analyze the attitude of society towards vaccination and the anti-vaccination movement. Materials and methods. In 2021-2022, 1510 people from various social groups underwent a voluntary anonymous survey using the author's questionnaire by use of Google Form. Results. The most common reason for refusal to vaccinate was fear of post-vaccination complications, the severity of which was influenced by the social affiliation, age, and health status of the respondents. According to the interviewed respondents, the obligatory nature of a certain vaccination was determined by: the degree of personal risk of contracting infection, the level of trust in the vaccine manufacturer, and previous experience. Some of the survey participants are not sufficiently informed about post-vaccination complications. The vast majority of respondents did not share the ideas of the anti-vaccine movement. Conclusion. Increasing the population's adherence to vaccination is a complex task, which requires a comprehensive interdepartmental approach targeted at those individuals who had a wary or negative attitude towards vaccination. One of the possible ways of such influence is to raise awareness on this issue. Keywords: attitude to vaccination, post-vaccination complications, refusal to vaccinate, anti-vaccination movement.
CLINICAL LABORATORY DIAGNOSTICS
STEROID METABOLOMICS IN WOMEN WITH NON-CLASSIC CONGENITAL ADRENAL HYPERPLASIA IN THE PRESENCE AND ABSENCE OF ADRENOCORTICAL MASSES OR MULTIFOLLICULAR OVARIES
E.V. Malevanaya1, L.I. Velikanova1, N.V. Vorokhobina1, O.B. Glavnova2, E.G. Strelnikova1, R.K. Galakhava1 1 North-Western State Medical University named after I.I. Mechnikov. Russia, 191015, Saint Petersburg, Kirochnaya street, 41 2Research Institute of Obstetrics and Gynecology named after D.O. Ott. Russia, 199034, Saint Petersburg, Mendeleevskaya line, 3 Abstract Introduction. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency is one of the main causes of hyperandrogenism. Chromatography-mass spectrometry methods are one of the key methods in the diagnosis of non-classic forms of congenital adrenal hyperplasia, since they allow to identify the precursors of key steroids and their metabolites. Aim of the study was to analyze the steroid metabolism by gas chromatography-mass spectrometry in women of reproductive age with non-classic form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency in combination with adrenocortical masses or multifollicular ovaries. Materials and methods. Urine steroid profiles were studied by gas chromatography-mass spectrometry in 42 women with non-classic form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency: in 19 women with hormonally inactive adrenocortical masses, in 9 patients with multifollicular ovaries and 14 women with only non-classic form of congenital adrenal hyperplasia. Results. The biomarkers threshold values of non-classic form of congenital hyperplasia due to 21-hydroxylase deficiency in patients without adrenocortical masses and multifollicular ovaries, in patients with adrenocortical masses were obtained: 11-oxo-pregnantriol more than 200 µg/24hr, the ratio of the sum of tetrahydro-metabolites of cortisol and cortisone to 11-oxo-pregnantriol less than 13; signs of an increase in the activity of 5α-reductase, a decrease in the activity of 11β-hydroxysteroid dehydrogenase type 1 and 3β-hydroxysteroid dehydrogenase. The main biomarker of 21-hydroxylase defect (the ratio of the sum of tetrahydro-metabolites of cortisol and cortisone to 11-oxo-pregnantriol) in patients with multifollicular ovaries was higher (more than 13) than in women from other studied groups. Additionally, in patients with adrenocortical masses, 11-oxo-pregnentriol, 5α-tetrahydro-11-dehydrocorticosterone, 5α-17-hydroxypregnanolone, and malignancy biomarkers (3β,16,20-pregnentriol and 3β,17,20-pregnentriol) were determined, which may play a role in the tactics of treating patients with non-classic form of congenital adrenal hyperplasia. Keywords: non-classic form of congenital adrenal hyperplasia due to 21-hydroxylase deficiency, adrenocortical masses, multifollicular ovaries, gas chromatography-mass spectrometry, urine steroid profile.
MACROTROPONINS IN THE BLOOD AS AN ANALYTICAL PROBLEM AND SOLUTIONS (REVIEWAND PERSONAL EXPERIENCE)
T.A. Sheshurina1,V.V. Dorofeykov1,2 1Lesgaft National State University of Physical Education, Sport and Health. Russia, 190121, Saint Petersburg , Dekabristov street, 35 2Almazov National Medical Research Centre. Russia, 197341, Saint Petersburg, Akkuratova street, 2 Abstract
The article analyzes the scientific data on laboratory methods for determining cardiac troponins, presents the study results on control materials for troponin I and troponin T. Analytical problems occurring at working on immunochemical analyzers of various manufacturers while performing troponin test are analyzed. In the last few years, there have been reports in the literature about the detection of macrocomplexes of troponin and immunoglobulins circulating in the bloodstream, which may result in false-positive test results for this important marker of myocardial damage. The main mechanisms of macrotroponins formation, the causes and frequency of their detection in the blood, including after a new coronavirus infection and vaccination, are considered. Based on our own experience and analysis of literature data, it was made the conclusions that would help practitioners correctly interpret the data of laboratory analysis for cardiac troponin Keywords: troponin I, troponin T, circulating immune complexes, macrotroponin, myocardial damage, deposition with polyethyleneglycol.
REGIONAL FEATURES OF FREQUENCIES DISTRIBUTION OF GENE POLYMORPHISM OF ARTERIAL HYPERTENSION IN NORTHERN RESIDENTS OF THE MAGADAN REGION
I.N. Bezmenova Scientific Research Center “Arktika”, Fareastern Branch of the Russian Academy of Sciences. Russia, 685000, Magadan, Karl Marx avenue, 24 Abstract Introduction. The Northern territories is the area of exposure to a complex of extreme environmental factors that are stressful for all human functional systems. Most researchers conclude that the climatic and geographical conditions of the north have a hypertensive effect on the human body. Modern healthcare system focuses on arterial hypertension as an urgent problem that becomes catastrophic in the North being the most common cause of early disability and mortality among northerners of employable age. Therefore, studies aimed to analyze the epidemiology of genes increasing the risk of arterial hypertension in the circumpolar zone are especially relevant. The aim of study is to estimation of the frequency of genes polymorphism of arterial hypertension (AGT (rs4762), AGTR1 (rs5186), ADD 1 (rs4961), NOS3 (rs2070744) and detect its regional features in the northern residents of the Magadan region. Materials and methods. The cross-sectional simultaneous study involved 101 practically healthy men from unrelated groups, mostly Caucasians, living or born in Magadan region. The mean age of the subjects was 46.12±1.5 years. Molecular genetic testing of genes that were directly involved in determining the performance of the main blood pressure regulation systems such as AGT, AGTR1, ADD1, eNOS3 by the PCR method was carried out. It was calculated phenotypical, gene frequencies, observed and expected levels of heterozygosity, genetic distances between populations (according to Nei), matrices of genetic distance were used for cluster analysis. Results. The frequencies of alleles that increase the risk of arterial hypertension in the northern residents of the Magadan region is: 0.1337 (AGT*T); 0.3564 (eNOS*C); 0.2550 (AGTR1*C); 0.1832 (ADD1*T). Conclusion. A regional peculiarity of the genetic profile of the northern population of the Magadan region is the trend of low frequencies of genes- polymorphism of arterial hypertension. Therefore, ethno-territorial picture of the genetic structure of population helps to create region-oriented diagnostic maps that allow to assess total risks for developing pathologies associated with cold exposure, as well as to make prompt lifestyle corrections, preventive and therapeutic measures. Key words: arterial hypertension, genetic polymorphism, adaptation, human populations, North.
(с) 2024 North-Western State Medical University named after I.I.Mechnikov
